Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology.

Title:

Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology.

identifier:	1642087
description:	epitope description:EFRHD antigen name:Amyloid beta A4 protein host organism:Mus musculus antibody name:2C1, 12B4, 3A3, 12A11
aggregation:	instance of dataset
availability:	available
primaryPublications:	12566568

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Fré dé rique Bard Robin Barbour Catherine Cannon Robert Carretto Michael Fox Dora Games Teresa Guido Kathleen Hoenow Kang Hu Kelly Johnson-Wood Karen Khan Dora Kholodenko Celeste Lee Mike Lee Ruth Motter Minh Nguyen Amanda Reed Dale Schenk Pearl Tang Nicki Vasquez Peter Seubert Ted Yednock

method:	biological activity

name:	Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology.
description:	The epitope-specific mAbs were able to clear amyloid plaque in vitro culture experiments compared to control cultures. The IgG2a mAbs 12B4 and 3C1 were more effective than the IgG2b mAbs 12A11and 3A3.

name:	iedb
homePage:	http://www.iedb.org

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