Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide. |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1008898 |
| landingPage: |
http://www.iedb.org/assay/1642625 |
| type: |
Literature
|
| publicationVenue: |
Proc Natl Acad Sci U S A
|
| dates: |
1996
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
B Solomon
R Koppel
E Hanan
|
| method: |
biological activity
|
| name: |
Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide.
|
| description: |
The epitope-specific mAb was able to inhibit the aggregation of A beta 1-40, and to induce conversion of beta amyloid from fibrillar to nonfibrillar conformation, as seen by electron microscopy and by thioflavin T-based fluorometric assay of fibril formation.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |