Alzheimer beta/A4-amyloid precursor protein: evidence for putative amyloidogenic fragment. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Alzheimer beta/A4-amyloid precursor protein: evidence for putative amyloidogenic fragment.

Dataset

identifier:	1642827
description:	epitope description:LVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ antigen name:Amyloid beta A4 protein host organism:Oryctolagus cuniculus
aggregation:	instance of dataset
availability:	available
primaryPublications:	1345769

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1014399
landingPage:	http://www.iedb.org/assay/1642827

Publication

type:	Literature
publicationVenue:	J Neurochem
dates:	1992

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	S E Gandy R Bhasin T V Ramabhadran E H Koo D L Price D Goldgaber P Greengard

Data Type

method:	western blot

Study

name:	Alzheimer beta/A4-amyloid precursor protein: evidence for putative amyloidogenic fragment.
description:	The epitope sequence was cited in Kang et al. (1987) Nature. Feb 19-25 325(6106):733-6 [PMID: 2881207]. The epitope-specific antiserum recognized the alternative spliced form of the amyloid precursor protein APP-751in Western Blot, using lystaes of Sf 9 cells infected with recombinant baculovirus. Antibody-immunoreactive proteins were identified as a high-molecular-mass species that failed to enter the gel (APP holoprotein) and discrete low-molecular-mass bands of 25, 17, 16, and 14 kDa.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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