Immunogenicity and therapeutic efficacy of phage-displayed beta-amyloid epitopes. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Immunogenicity and therapeutic efficacy of phage-displayed beta-amyloid epitopes.

Dataset

identifier:	1643001
description:	epitope description:AEFRH antigen name:Amyloid beta A4 protein host organism:Mus musculus APP
aggregation:	instance of dataset
availability:	available
primaryPublications:	17850871

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1011664
landingPage:	http://www.iedb.org/assay/1643001

Publication

type:	Literature
publicationVenue:	Mol Immunol
dates:	2008

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Marianna Esposito Ilaria Luccarini Valeria Cicatiello Diana De Falco Anna Fiorentini Pasquale Barba Fiorella Casamenti Antonella Prisco

Data Type

method:	ELISA

Study

name:	Immunogenicity and therapeutic efficacy of phage-displayed beta-amyloid epitopes.
description:	The antibodies were tested against A beta 1-11. Similar results were seen with non-transgenic B6C3 and with Balb/c mice. Immunization with the epitope produced higher IgM titers against fragment A beta 1-11 than immunization with either A beta 1-7 or with A beta 1-42. The optimal antibody response following epitope immunization requires a threshold dose of antigen, in this case 50 ug doses or more. The most prevalent isotype is IgG2b, followed by IgG2a, IgG3 and then by IgG1.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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