CD40L disruption enhances Abeta vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation.

Title:

CD40L disruption enhances Abeta vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation.

identifier:	1643113
description:	epitope description:DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA antigen name:Amyloid beta A4 protein host organism:Mus musculus APPsw
aggregation:	instance of dataset
availability:	available
primaryPublications:	18055209

study type:	b cell assays
subject species:	Homo sapiens

fullName:	D Obregon H Hou Y Bai W V Nikolic Deyan Luo J Zeng J Ehrhart F Fernandez D Morgan B Giunta J Tan

method:	ELISA

name:	CD40L disruption enhances Abeta vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation.
description:	The epitope vaccination of mice completely (PSAPP/CD40−/−) and partially (PSAPP/CD40+/−) deficient for CD40 yielded decreased amounts of the soluble and insoluble epitope in brain homogenates compared to those of wild type PSAPP mice. In another experiment, peripheral and cerebral Abeta1-42 levels are reduced in the epitope-immunized PSAPP mice treated with CD40L neutralizing antibody.

name:	iedb
homePage:	http://www.iedb.org

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