Mapping of immune responses following wild-type and mutant ABeta42 plasmid or peptide vaccination in different mouse haplotypes and HLA Class II transgenic mice.

Title:

Mapping of immune responses following wild-type and mutant ABeta42 plasmid or peptide vaccination in different mouse haplotypes and HLA Class II transgenic mice.

Dataset

identifier:	1643820
description:	epitope description:DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA antigen name:Amyloid beta A4 protein host organism:Mus musculus C57BL/6
aggregation:	instance of dataset
availability:	available
primaryPublications:	16157426

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1014412
landingPage:	http://www.iedb.org/assay/1643820

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	2006

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Michele A Kutzler Chuanhai Cao Yun Bai Huiqin Dong Philip Y Choe Vera Saulino Laura McLaughlin Alex Whelan Andrew Y Choo David B Weiner Kenneth E Ugen

Data Type

method:	ELISA

Study

name:	Mapping of immune responses following wild-type and mutant ABeta42 plasmid or peptide vaccination in different mouse haplotypes and HLA Class II transgenic mice.
description:	Vaccination with the epitope having either DM (Glu mutated to Gln at position 22) or FM ( Ala mutated to Gly at position 21) significantly enhanced the humoral immune responses in the C57BL/6 mice.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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