Arthritogenic antibodies specific for a major type II collagen triple-helical epitope bind and destabilize cartilage independent of inflammation.

Title:

Arthritogenic antibodies specific for a major type II collagen triple-helical epitope bind and destabilize cartilage independent of inflammation.

identifier:	1643986
description:	epitope description:LVGPRGERGFP antigen name:Collagen alpha-1(II) chain host organism:Rattus norvegicus DA
aggregation:	instance of dataset
availability:	available
primaryPublications:	18163493

study type:	b cell assays
subject species:	Rattus norvegicus

fullName:	Kutty Selva Nandakumar Estelle Bajtner Leigh Hill Beate Bö hm Merrill J Rowley Harald Burkhardt Rikard Holmdahl

method:	ELISA

name:	Arthritogenic antibodies specific for a major type II collagen triple-helical epitope bind and destabilize cartilage independent of inflammation.
description:	This conserved sequence is also present in human, bovine and mouse Collagen alpha-1 type II. The antigen is a triple helical peptide where the strands are covalently linked at the C-terminus. It was recognized as early as 15 days after the immunization, and the reactivity was maximal 28 days after the immunization, when arthritis was detected.

name:	iedb
homePage:	http://www.iedb.org

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