Arthritogenic antibodies specific for a major type II collagen triple-helical epitope bind and destabilize cartilage independent of inflammation.

Title:

Arthritogenic antibodies specific for a major type II collagen triple-helical epitope bind and destabilize cartilage independent of inflammation.

identifier:	1644026
description:	epitope description:MPGERGAAGIAGPK antigen name:Collagen alpha-1(II) chain host organism:Mus musculus DBA/1
aggregation:	instance of dataset
availability:	available
primaryPublications:	18163493

study type:	b cell assays
subject species:	Mus musculus

fullName:	Kutty Selva Nandakumar Estelle Bajtner Leigh Hill Beate Bö hm Merrill J Rowley Harald Burkhardt Rikard Holmdahl

method:	in vivo assay

name:	Arthritogenic antibodies specific for a major type II collagen triple-helical epitope bind and destabilize cartilage independent of inflammation.
description:	This conserved sequence is also present in human and rat Collagen alpha-1 type II. Mice that were injected with the epitope-specific mAb developed arthritis after an i.p. LPS dose. Combination with other arthritogenic mAbs enhanced the disease scores both before and after LPS injection.

name:	iedb
homePage:	http://www.iedb.org

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