Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location.

Title:

Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location.

identifier:	1644047
description:	epitope description:GDRSGYSSPGSPG antigen name:Microtubule-associated protein tau host organism:Mus musculus BALB/c antibody name:Tau-1
aggregation:	instance of dataset
availability:	available
primaryPublications:	7680727

study type:	b cell assays
subject species:	Homo sapiens

fullName:	G I Szendrei V M Lee L Otvos Jr

method:	antigen inhibition

name:	Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location.
description:	The epitope successfully competed with the T1 epitope (189-207) for binding to the Tau-1 mAb. Similar results were seen in solid-phase and liquid-phase ELISA. Monophosphorylation of Ser202, 199, 198, or 195 disrupted binding. Mutation of Ser195 to Ala had no effect on binding.

name:	iedb
homePage:	http://www.iedb.org

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