Fine mapping of diabetes-associated IA-2 specific autoantibodies. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Fine mapping of diabetes-associated IA-2 specific autoantibodies.

Dataset

identifier:	1644058
description:	epitope description:PAEGT antigen name:Receptor-type tyrosine-protein phosphatase-like N host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	14624760

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1007490
landingPage:	http://www.iedb.org/assay/1644058

Publication

type:	Literature
publicationVenue:	J Autoimmun
dates:	2003

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Massimo Bearzatto Vito Lampasona Cristina Belloni Ezio Bonifacio

Data Type

method:	immunoprecipitation

Study

name:	Fine mapping of diabetes-associated IA-2 specific autoantibodies.
description:	The epitope sequence was derived from the sequence found in the cited reference, Bonifacio et al, J Immunol. 161:2648 (1998) [PMID: 9725268]. The epitope was deduced by analysis of the reactivity to the WT IA-2 C-terminal fragment (including the Juxta-membrane and the PTP-like domains), that was abolished or reduced in the patients when the epitope residues at positions 1,2,3 and 5 mutated to those in the homologous protein IA-2beta PTP-like domain, which the patients don't recognize. The Gly at positon 4 is conserved with IA-2beta, and therefore was not mutated.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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