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Title: Mapping and molecular characterization of novel monoclonal antibodies to conformational epitopes on NH2 and COOH termini of mammalian tryptophanyl-tRNA synthetase reveal link of the epitopes to aggregation and Alzheimer's disease.
identifier: 1644898
description:
epitope description:SKDEIDSAVKMLVSLKMSY
antigen name:Tryptophan--tRNA ligase, cytoplasmic
host organism:Mus musculus BALB/c
antibody name:9D7 (mAb B2)
aggregation:
instance of dataset
availability:
available
primaryPublications: 16616781
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1008729
landingPage: http://www.iedb.org/assay/1644898
type:
Literature
publicationVenue:
Mol Immunol
dates:
2007
study type: b cell assays
subject species: Homo sapiens
fullName:
Elena L Paley
Larisa Smelyanski
Vladimir Malinovskii
Pochi R Subbarayan
Yevgeny Berdichevsky
Natalia Posternak
Jonathan M Gershoni
Olga Sokolova
Galina Denisova
method:
antigen inhibition
name:
Mapping and molecular characterization of novel monoclonal antibodies to conformational epitopes on NH2 and COOH termini of mammalian tryptophanyl-tRNA synthetase reveal link of the epitopes to aggregation and Alzheimer's disease.
description:
The mAb bound to the epitope in ELISA. The epitope inhibited the mAb binding to cellular TrpRS in human cells analyzed by immunohistochemistry.

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