Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1497 |
| landingPage: |
http://www.iedb.org/assay/1645146 |
| type: |
Literature
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| publicationVenue: |
J Virol
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| dates: |
1997
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| study type: | b cell assays |
| subject species: | Influenza A virus (A/X-31(H3N2)) |
| fullName: |
S Laeeq
C A Smith
S D Wagner
D B Thomas
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| method: |
biological activity
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| name: |
Preferential selection of receptor-binding variants of influenza virus hemagglutinin by the neutralizing antibody repertoire of transgenic mice expressing a human immunoglobulin mu minigene.
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| description: |
Escape mutants selected with the mAb, derived from human IgM expressing mice, were sequenced to determine the epitope. Also the and its neuramidase treated mAbs were used. This mAb selected residues G151 and G174 in one round of selection and residues S161 and G174 in another. The laboratory variants and those selected with other mAbs carrying mutations in one or more of these residues were also less well recognized by this mAb in HI and ELISA, as well as those carrying a mutation in the nearby residue L242. The mAb also had no or lower HI activity towards JAP/57 (subtype H2), PR8/34 (subtype H1) and H3 subtype viruses HK/71, PC/73, VIC/75 and TEX/77.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
