Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1014525 |
| landingPage: |
http://www.iedb.org/assay/1645237 |
| type: |
Literature
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| publicationVenue: |
Arthritis Rheum
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| dates: |
2008
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| study type: | b cell assays |
| subject species: |
| fullName: |
Kexing Fan
Jianxin Dai
Hao Wang
Huafeng Wei
Zhiguo Cao
Sheng Hou
Weizhu Qian
Huaqing Wang
Bohua Li
Jian Zhao
Huji Xu
Chengde Yang
Yajun Guo
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| method: |
in vivo assay
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| name: |
Treatment of collagen-induced arthritis with an anti-osteopontin monoclonal antibody through promotion of apoptosis of both murine and human activated T cells.
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| description: |
Administration of the epitope specific monoclonal antibody protected mice from collagen induced arthritis in DBA/1J mice as measured by clinical score, TNFalpha, IL-1beta, and IL-6 mRNA levels. T-cell apoptosis, measured by TUNEL assay, was also observed in CIA mice treated with the monoclonal antibody with upregulation of Bim and Bax and downregulation of Bcl-2. NF-κB was also suppressed by the epitope specific monoclonal antibody.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
