Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1014021 |
| landingPage: |
http://www.iedb.org/assay/1645678 |
| type: |
Literature
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| publicationVenue: |
Am J Respir Cell Mol Biol
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| dates: |
1999
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| study type: | b cell assays |
| subject species: | Gallus gallus |
| fullName: |
E M Janssen
M H Wauben
E H Jonker
G Hofman
W Van Eden
F P Nijkamp
A J Van Oosterhout
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| method: |
in vivo assay
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| name: |
Opposite effects of immunotherapy with ovalbumin and the immunodominant T-cell epitope on airway eosinophilia and hyperresponsiveness in a murine model of allergic asthma.
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| description: |
The epitope sequence is derived from Shimonkevitz et al., J Immunol 133 (4): 2067 (1984) [PMID: 6332146].
The response to aerosol OVA challenge in mice that received immunotreatment with the epitope 2 days before was not better than those that received saline treatment. OVA-specific IgG1, IgG2a and IgE were similar in both groups. Indeed, the treatment enhanced the sensitivity as measured by hyperresponsiveness to the effect of intravenous administration of methacholine in the increase in airway resistance and a significant increase in eosinophils and neutrophils, but not in mononuclear cells or lymphocytes, in the bronchoalveolar lavage fluid.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
