Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model.

Title:

Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model.

identifier:	1646660
description:	epitope description:DAEFRHDSGYEVHHQK antigen name:Amyloid beta A4 protein host organism:Mus musculus antibody name:Ab9, Ab5
aggregation:	instance of dataset
availability:	available
primaryPublications:	16341263

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Yona Levites Pritam Das Robert W Price Marjorie J Rochette Lisa A Kostura Eileen M McGowan Michael P Murphy Todd E Golde

method:	ELISA

name:	Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model.
description:	Passive immunotherapy into 7-month old Tg2576 mice or 3-month-old CRND8 mice with the epitope specific mAb (Ab9) significantly attenuated Abeta ( AA; 1-40 and 1-42) level following SDS or formic acid extraction by ELISA, but not in 11-month-old Tg2576 mice. Passive immunotherapy into 10-month-old Tg2576 mice with the epitope specific mAb ( Ab9, Ab5) significantly attenuated Abeta ( AA; 1-40 and 1-42) level following SDS or formic acid extraction by ELISA.

name:	iedb
homePage:	http://www.iedb.org

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