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identifier: 1647126
description:
epitope description:SQTTANPSCPEGT
antigen name:Protein LOC100911572
host organism:Rattus norvegicus Wistar
aggregation:
instance of dataset
availability:
available
primaryPublications: 17005930
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1014714
landingPage: http://www.iedb.org/assay/1647126
type:
Literature
publicationVenue:
J Am Soc Nephrol
dates:
2006
study type: b cell assays
subject species: Rattus norvegicus
fullName:
Lanlin Chen
Thomas Hellmark
Vadim Pedchenko
Billy G Hudson
Charles D Pusey
Jay W Fox
W Kline Bolton
method:
ELISA
name:
A nephritogenic peptide induces intermolecular epitope spreading on collagen IV in experimental autoimmune glomerulonephritis.
description:
A significant increase in serum antibody to alpha3(IV)NC1 and alpha4(IV)NC1 domains was evident by 4 weeks after immunization with the epitope. Antibodies that were eluted from human kidneys of nephritic rats also bound to human 3(IV)NC1in ELISA or Western blot, and in addition stained rat kidney sections in indirect immunofluorescence.

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