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Title: Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.
identifier: 1647435
description:
epitope description:LVFFAEDV
antigen name:Amyloid beta A4 protein
host organism:Mus musculus
aggregation:
instance of dataset
availability:
available
primaryPublications: 15834427
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1008733
landingPage: http://www.iedb.org/assay/1647435
type:
Literature
publicationVenue:
Nat Med
dates:
2005
study type: b cell assays
subject species: Homo sapiens
fullName:
Igor Klyubin
Dominic M Walsh
Cynthia A Lemere
William K Cullen
Ganesh M Shankar
Vicki Betts
Edward T Spooner
Liying Jiang
Roger Anwyl
Dennis J Selkoe
Michael J Rowan
method:
biological activity
name:
Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.
description:
The epitope-specific mAb was able to inhibit the amyloid-induced long term potentiation, a correlate of learning and memory, in the brain when injected into intracerebrally into a rat.

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