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Title: Direct in vivo intracellular selection of conformation-sensitive antibody domains targeting Alzheimer's amyloid-beta oligomers.
identifier: 1648856
description:
epitope description:GAIIGLMVGGVVIA
antigen name:Amyloid beta A4 protein
host organism:Mus musculus BALB/c
antibody name:A1, A13, A18, A19
aggregation:
instance of dataset
availability:
available
primaryPublications: 19361429
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1014195
landingPage: http://www.iedb.org/assay/1648856
type:
Literature
publicationVenue:
J Mol Biol
dates:
2009
study type: b cell assays
subject species: Homo sapiens
fullName:
Giovanni Meli
Michela Visintin
Isabella Cannistraci
Antonino Cattaneo
method:
biological activity
name:
Direct in vivo intracellular selection of conformation-sensitive antibody domains targeting Alzheimer's amyloid-beta oligomers.
description:
The epitope was deduced from testing a series of Abeta deletion mutants. The epitope sequence is conserved between mouse and human.
The epitope specific monoclonal single chain Fv antibody fragments bound the Abeta 1-40 in a yeast 2-hybrid assay.

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