The natural human IgG anti-F(ab')2 antibody recognizes a conformational IgG1 hinge epitope. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

The natural human IgG anti-F(ab')2 antibody recognizes a conformational IgG1 hinge epitope.

Dataset

identifier:	1649359
description:	epitope description:TCPPCPAPELLGG antigen name:Immunoglobulin host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	7539020

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1011248
landingPage:	http://www.iedb.org/assay/1649359

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	1995

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	P Terness I Kohl G Hü bener R Battistutta L Moroder M Welschof C Dufter M Finger C Hain M Jung

Data Type

method:	antigen inhibition

Study

name:	The natural human IgG anti-F(ab')2 antibody recognizes a conformational IgG1 hinge epitope.
description:	Increasing amounts of the epitope lead to a gradual inhibition of anti-F(ab')₂ activity. This inhibition was observed to be strongest against a synthetic double chain molecule, in which each chain represented the epitope hinged at Cys2 and Cys5, creating a cyclic region between the two cysteine bridges, plus an exocyclic region. The monomeric form of the epitope inhibited binding poorly. This suggest that the IgG anti-F(ab')₂ antibodies recognize a conformational IgG1 hinge epitope.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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