Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis. |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1015101 |
| landingPage: |
http://www.iedb.org/assay/1652924 |
| type: |
Literature
|
| publicationVenue: |
Arthritis Rheum
|
| dates: |
2001
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
C C Reparon-Schuijt
W J van Esch
C van Kooten
G A Schellekens
B A de Jong
W J van Venrooij
F C Breedveld
C L Verweij
|
| method: |
ELISA
|
| name: |
Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis.
|
| description: |
The epitope sequence is reported in Schellekens et al., J Clin Invest. 1998 Jan 1
101(1):273-81. [PMID: 9421490].
IgM–anti-CCP autoantibodies were induced in peripheral blood B cells from healthy controls and RA patients following coculture with activated T cells or application of the CD40 activation system, whereas no production could be detected when peripheral blood B cells were cultured in the absence of a stimulus. Synovial fluid and bone marrow B cells from anti-CCP–seropositive RA patients, but not anti- CCP–seronegative patients, actively produced IgM–anti- CCP without stimulation, providing evidence for antigen-driven maturation of CCP-specific B cells at the site of inflammation in RA.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |