Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1015103 |
| landingPage: |
http://www.iedb.org/assay/1650599 |
| type: |
Literature
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| publicationVenue: |
Arthritis Rheum
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| dates: |
2000
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| study type: | b cell assays |
| subject species: |
| fullName: |
E J Kroot
B A de Jong
M A van Leeuwen
H Swinkels
F H van den Hoogen
M van't Hof
L B van de Putte
M H van Rijswijk
W J van Venrooij
P L van Riel
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| method: |
ELISA
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| name: |
The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis.
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| description: |
The epitope sequence is reported in Schellekens et al., Arthritis Rheum. 2000 Jan
43(1):155-63. [PMID: 10643712]. Cysteine substitutions were made to facilitate formation of a cyclic peptide.
The responses of recent-onset RA patients to the peptide were determined, and statistical analyses were later performed to quantify the predictive value of these responses for future severity of disease. Patients with anti-CCP had developed significantly more severe radiologic damage after 6 years of follow-up. In multiple regression analysis, radiologic damage after 6 years follow-up was significantly predicted by IgM-RF status, radiologic score at entry, and anti-CCP status. Functional disability was significantly predicted by sex, age at entry, IgM-RF status, and DAS.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
