Characterization of a novel protective monoclonal antibody that recognizes an epitope common to Vibrio cholerae Ogawa and Inaba serotypes.

Title:

Characterization of a novel protective monoclonal antibody that recognizes an epitope common to Vibrio cholerae Ogawa and Inaba serotypes.

identifier:	1650715
description:	epitope description:FCQPHLSCYILP host organism:Mus musculus BALB/c antibody name:mAb 72.1
aggregation:	instance of dataset
availability:	available
primaryPublications:	19389772

study type:	b cell assays
subject species:

fullName:	Madushini N Dharmasena Shelly J Krebs Ronald K Taylor

method:	biological activity

name:	Characterization of a novel protective monoclonal antibody that recognizes an epitope common to Vibrio cholerae Ogawa and Inaba serotypes.
description:	The peptide is a ligand of an anti-LPS mAb that reacts with both Ogawa and Inaba serotypes of LPS from V. cholerae. Incubation of Vibrio cholerae of Ogawa and Inaba serotypes with the epitope-specific mAb prior to infection was protective in an infant mouse challenge model. The mAb is also shown to label both serotypes of V. cholerae in Immuno-field emission scanning electron microscopy.

name:	iedb
homePage:	http://www.iedb.org

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