Arthritis-related B cell epitopes in collagen II are conformation-dependent and sterically privileged in accessible sites of cartilage collagen fibrils.

Title:

Arthritis-related B cell epitopes in collagen II are conformation-dependent and sterically privileged in accessible sites of cartilage collagen fibrils.

Dataset

identifier:	1651018
description:	epitope description:ARGLTGRPGDA antigen name:Collagen alpha-1(II) chain host organism:Mus musculus DBA/1 antibody name:D8, CB 300, CB 313, M2 87, M2 88
aggregation:	instance of dataset
availability:	available
primaryPublications:	9430695

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1014672
landingPage:	http://www.iedb.org/assay/1651018

Publication

type:	Literature
publicationVenue:	J Biol Chem
dates:	1998

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	S Schulte C Unger J A Mo O Wendler E Bauer S Frischholz K von der Mark J R Kalden R Holmdahl H Burkhardt

Data Type

method:	ELISA

Study

name:	Arthritis-related B cell epitopes in collagen II are conformation-dependent and sterically privileged in accessible sites of cartilage collagen fibrils.
description:	The epitope was deduced. The epitope sequence is found in collagen II from human,rat, and other species. The epitope of the mAbs was determined using recombinant collagen II/collagen X chimeras (truncation analysis) and ELISA. The mAb isotypes are: IgG3 (D8), IgG2b (CB 300, CB 313), IgG2a (M2 87, M2 88).

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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