Physical mapping of human insulin-like growth factor-I using specific monoclonal antibodies. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Physical mapping of human insulin-like growth factor-I using specific monoclonal antibodies.

Dataset

identifier:	1653813
description:	epitope description:DRGFYFNKPTGY antigen name:Insulin-like growth factor I (UniProt:P05019) host organism:Mus musculus antibody name:BA5F11, BB11D3
aggregation:	instance of dataset
availability:	available
primaryPublications:	9291840

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1014475
landingPage:	http://www.iedb.org/assay/1653813

Publication

type:	Literature
publicationVenue:	J Endocrinol
dates:	1997

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	S Mañ es L Kremer B Vangbo A Ló pez C Gó mez-Mouton E Peiró J P Albar I B Mendel-Hartvig R Llopis C Martí nez

Data Type

method:	radio immuno assay (RIA)

Study

name:	Physical mapping of human insulin-like growth factor-I using specific monoclonal antibodies.
description:	The epitope-specific mAbs recognized recombinant human IGF-1 in RIA and ELISA. Cross reactivity to other IGFs and mutants was tested, with these mAbs partially cross-reacting with chicken IGF-I. Glycosylated IGF-I, IGF-II, and IGF-I mutants lacking residues 1-3 at the N-terminus of the mature chain, or with residue 3 exchanged from E to R, or with mismatched S-S linkages, are recognized at the same level as the recombinant IGF-I. The mAbs did not react with human insulin.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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