Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1012958 |
| landingPage: |
http://www.iedb.org/assay/1653647 |
| type: |
Literature
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| publicationVenue: |
Toxicology
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| dates: |
2008
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| study type: | b cell assays |
| subject species: |
| fullName: |
C Frieke Kuper
Rob H Stierum
Andre Boorsma
Marcel A Schijf
Menk Prinsen
Joost P Bruijntjes
Nanne Bloksma
Josje H E Arts
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| method: |
in vivo assay
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| name: |
The contact allergen dinitrochlorobenzene (DNCB) and respiratory allergy in the Th2-prone Brown Norway rat.
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| description: |
Macroscopic and microscopic skin allergy symptoms were enhanced in sensitized rats after a cutaneous challenge with DNCB (topical patch with 0.1% DNCB applied for 24 h to the flank, calculated total dose 30μg) at day 16 after the 1st sensitizing dose, compared to the response in unsensitized, challenged group. The response was higher in this Th1 response-prone strain than in Th2-prone Black Norway rats.
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| name: |
iedb
|
| homePage: |
http://www.iedb.org |
