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Title: Overcoming antigen masking of anti-amyloidbeta antibodies reveals breaking of B cell tolerance by virus-like particles in amyloidbeta immunized amyloid precursor protein transgenic mice.
identifier: 1655529
description:
epitope description:DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
antigen name:Amyloid beta A4 protein
host organism:Mus musculus APPsw
aggregation:
instance of dataset
availability:
available
primaryPublications: 15186505
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1015801
landingPage: http://www.iedb.org/assay/1655529
type:
Literature
publicationVenue:
BMC Neurosci
dates:
2004
study type: b cell assays
subject species: Homo sapiens
fullName:
Qingyou Li
Chuanhai Cao
Bryce Chackerian
John Schiller
Marcia Gordon
Kenneth E Ugen
Dave Morgan
method:
antigen inhibition
name:
Overcoming antigen masking of anti-amyloidbeta antibodies reveals breaking of B cell tolerance by virus-like particles in amyloidbeta immunized amyloid precursor protein transgenic mice.
description:
The antiserum was incubated at pH 2.5 or pH 7 in competition assay or direct ELISA. The antiserum did not react with the epitope at pH 7 in direct ELISA. The antibody titer was higher in the transgenic mice compared to the non transgenic littermates.

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