A synthetic peptide from the third hypervariable region of major histocompatibility complex class II beta chain as a vaccine for treatment of experimental autoimmune encephalomyelitis.

Title:

A synthetic peptide from the third hypervariable region of major histocompatibility complex class II beta chain as a vaccine for treatment of experimental autoimmune encephalomyelitis.

Dataset

identifier:	1661931
description:	epitope description:AEYYNKQYLEQTRAELDT antigen name:H-2 class II histocompatibility antigen, A-S beta chain host organism:Mus musculus SJL
aggregation:	instance of dataset
availability:	available
primaryPublications:	8058747

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1015602
landingPage:	http://www.iedb.org/assay/1661931

Publication

type:	Literature
publicationVenue:	Proc Natl Acad Sci U S A
dates:	1994

Dimension

study type:	b cell assays
subject species:	Mus musculus

Person

fullName:	D J Topham B Nag S Arimilli S Sriram

Data Type

method:	in vivo assay

Study

name:	A synthetic peptide from the third hypervariable region of major histocompatibility complex class II beta chain as a vaccine for treatment of experimental autoimmune encephalomyelitis.
description:	Immunization with the epitope reduced the incidence of EAE induced by spinal cord homogenate and reduced the incidence of relapses induved by adoptive transfer of MBP-sensitized T lymphocytes. Immunization with a 10-mer epitope spanning residues 4 - 13 of the epitope did not confer protection.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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