Generation, characterization and epitope mapping of two neutralizing and protective human recombinant antibodies against influenza A H5N1 viruses.

Title:

Generation, characterization and epitope mapping of two neutralizing and protective human recombinant antibodies against influenza A H5N1 viruses.

Dataset

identifier:	1658531
description:	epitope description:IIPKSSWS antigen name:Hemagglutinin host organism:Homo sapiens antibody name:AVEFluIgG01
aggregation:	instance of dataset
availability:	available
primaryPublications:	19421326

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1016036
landingPage:	http://www.iedb.org/assay/1658531

Publication

type:	Literature
publicationVenue:	PLoS One
dates:	2009

Dimension

study type:	b cell assays
subject species:	Influenza A virus (A/Anhui/1/2005(H5N1))

Person

fullName:	Lina Sun Xiuhua Lu Chuan Li Min Wang Qinzhi Liu Zi Li Xiaofen Hu Jiandong Li Feng Liu Qun Li Jessica A Belser Kathy Hancock Yuelong Shu Jacqueline M Katz Mifang Liang Dexin Li

Data Type

method:	biological activity

Study

name:	Generation, characterization and epitope mapping of two neutralizing and protective human recombinant antibodies against influenza A H5N1 viruses.
description:	The authors provided Genebank accession DQ371928 for the H5N1 A/Anhui/1/2005 strain. The epitope-specific mAb was capable of neutralizing other H5N1 viruses (clades 0, 1, 2.1, .2.2 and 2.3). Similar reactivity was observed by ELISA.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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