Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1667737 |
| description: |
epitope description:A: K243, D246, P248, L249, N250, P380, Q381, Y382, H383; B: I231, H234, E235
antigen name:H(+)/Cl(-) exchange transporter ClcA
host organism:Mus musculus
antibody name:anti-ClC Fab
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
12649487 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1001548 |
| landingPage: |
http://www.iedb.org/assay/1667737 |
| type: |
Literature
|
| publicationVenue: |
Science
|
| dates: |
2003
|
| study type: | b cell assays |
| subject species: | Escherichia coli K-12 |
| fullName: |
Raimund Dutzler
Ernest B Campbell
Roderick MacKinnon
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| method: |
x-ray crystallography
|
| name: |
Gating the selectivity filter in ClC chloride channels.
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| description: |
The epitope residues are calculated based on the Fab-antigen complex structures [PDB: 1OTS, 1OTT, 1OTU] as the protein antigen residues consisting of at least one atom separated from any antibody atom at or less than 4 Å
distance. The epitope is located on both polypeptide chains of the antigen homodimer.
The epitope of the anti-ClC Fab on a ClC homodimer containing the E148A mutation was determined from the crystal structure of the complex. The asymmetric unit contains the ClC homodimer crystallized with two Fab molecules, each recognizing similar epitopes located on both subunits of the dimer. The mutation is not involved in the epitope.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
