Identification of human papillomavirus type 16 L1 surface loops required for neutralization by human sera.

Title:

Identification of human papillomavirus type 16 L1 surface loops required for neutralization by human sera.

identifier:	1664531
description:	epitope description:L286, A290, A292, N296, D299, T309, N311, S314, N316, S375, T376, E378, Y381, N383, T384 antigen name:Major capsid protein L1 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	16641259

study type:	b cell assays
subject species:	Human papillomavirus type 16

fullName:	Joseph J Carter Greg C Wipf Margaret M Madeleine Stephen M Schwartz Laura A Koutsky Denise A Galloway

method:	biological activity

name:	Identification of human papillomavirus type 16 L1 surface loops required for neutralization by human sera.
description:	The epitope sequence was previously described in Carter et al, J Virol:77(21) 2003 [PMID:14557648]. Mutation of the epitotic residues eliminated the ability of the VLP to absorb the neutralizing activity of the sera. Mutation of the HPV31 VLP to match the sequence of the HPV16 VLP partially transferred the ability to absorb neutralizing antibodies.

name:	iedb
homePage:	http://www.iedb.org

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