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Title: The use of hapten-polysaccharide conjugates for the induction of B-cell tolerance involving IgE responses. II. Specific tolerance induced by sulphonamide-substituted levan in the mouse.
identifier: 1665167
description:
epitope description:4-sulfanilamidobenzoic acid
host organism:Mus musculus CBA
aggregation:
instance of dataset
availability:
available
primaryPublications: 313909
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1012997
landingPage: http://www.iedb.org/assay/1665167
type:
Literature
publicationVenue:
Int Arch Allergy Appl Immunol
dates:
1979
study type: b cell assays
subject species:
fullName:
M J Garrido
C Moreno
method:
in vivo assay
name:
The use of hapten-polysaccharide conjugates for the induction of B-cell tolerance involving IgE responses. II. Specific tolerance induced by sulphonamide-substituted levan in the mouse.
description:
Intravenous injection of large doses (0.1 and 1 mg) of 4-SABA conjugated to the polysaccharide levan before immunization with 4-SABA-CGG induced complete tolerance to the epitope 4-SABA. High doses of 4-SABA-Le depressed a secondary response to an additional challenge with 4-SABA-CGG on day 196. The antisera were titered by passive cutaneous anaphylaxis in Wistar rats. Spleen cells from mice made tolerant by injection of 10 µg 4-SABA-Le adoptively transferred into irradiated syngeneic mice did not inhibit he anti-4-SABA IgE response.

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