Reductively aminated D-xylose-albumin conjugate as the immunogen for generation of IgG and IgE antibodies specific to D-xylitol, a haptenic allergen.

Title:

Reductively aminated D-xylose-albumin conjugate as the immunogen for generation of IgG and IgE antibodies specific to D-xylitol, a haptenic allergen.

Dataset

identifier:	1665272
description:	epitope description:D-xylopyranose host organism:Oryctolagus cuniculus New Zealand White
aggregation:	instance of dataset
availability:	available
primaryPublications:	17979222

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1012662
landingPage:	http://www.iedb.org/assay/1665272

Publication

type:	Literature
publicationVenue:	Bioconjug Chem
dates:	2007

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Kundimi Sreenath Yeldur P Venkatesh

Data Type

method:	antigen inhibition

Study

name:	Reductively aminated D-xylose-albumin conjugate as the immunogen for generation of IgG and IgE antibodies specific to D-xylitol, a haptenic allergen.
description:	Reactivity of affinity-purified anti D-xylitol antibodies was tested in inhibition ELISA with various sugars, sugar alcohols, and other small molecules. Inhibition of binding to D-xylitol was found to be low for all molecules tested, with almost no recognition of 2-, 3-, and 4-carbon alcohols, implying that that the portion of xylitol molecule representing carbon atoms 2 to 5 most likely represents a single epitope.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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