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Title: High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase.
identifier: 1665412
description:
epitope description:E264
antigen name:Glutamate decarboxylase 2
host organism:Homo sapiens
antibody name:M10 (MICA-10)
aggregation:
instance of dataset
availability:
available
primaryPublications: 10222205
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1014039
landingPage: http://www.iedb.org/assay/1665412
type:
Literature
publicationVenue:
J Mol Biol
dates:
1999
study type: b cell assays
subject species: Homo sapiens
fullName:
H L Schwartz
J M Chandonia
S F Kash
J Kanaani
E Tunnell
A Domingo
F E Cohen
J P Banga
A M Madec
W Richter
S Baekkeskov
method:
immunoprecipitation
name:
High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase.
description:
The epitope recognized by human mAb M10 was deduced based on reactivity with GAD65/67 chimeric proteins. Swapping residues 242-282 of GAD65 with those from GAD67 abolished reactivity with M10. Single amino acid substitution of E264T in this region abolished reactivity with M10, indicating it is a critical residue.

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