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Title: Comparison of the antibody response to bee venom phospholipase A2 induced by natural exposure in humans or by immunization in mice.
identifier: 1666719
description:
epitope description:EHPVTGCGERTEGRCLHYTV
antigen name:Api m 1
host organism:Mus musculus BALB/c
antibody name:3F3, 1D12, 3H8, 1C11, 2B6, 2F5
aggregation:
instance of dataset
availability:
available
primaryPublications: 9376132
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1005223
landingPage: http://www.iedb.org/assay/1666719
type:
Literature
publicationVenue:
J Mol Recognit
dates:
1997
study type: b cell assays
subject species: Apis mellifera
fullName:
T Schneider
R R Annand
M H Gelb
T P King
M Suter
method:
biological activity
name:
Comparison of the antibody response to bee venom phospholipase A2 induced by natural exposure in humans or by immunization in mice.
description:
The epitope sequence is from the reference cited: Kuchler et al. (1989) Eur. J. Biochem. 184: 249-254 [PMID: 2776767]. The epitope was deduced.
The binding of epitope-reactive mAbs 1D12, 1C11, and 2B6 inhibited the enzymatic activity of native PLA2 by 66-70%, and mAbs 3F3, 2F5 and 3H8 inhibited activity by 30-50%.

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