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Title: The nature of the antigen-antibody complexes initiating the specific wheal-and-flare reaction in sensitized man.
identifier: 1674641
description:
epitope description:benzylpenicilloyl group
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 5637143
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1012630
landingPage: http://www.iedb.org/assay/1674641
type:
Literature
publicationVenue:
J Clin Invest
dates:
1968
study type: b cell assays
subject species:
fullName:
B B Levine
A P Redmond
method:
in vivo skin test
name:
The nature of the antigen-antibody complexes initiating the specific wheal-and-flare reaction in sensitized man.
description:
In general, bivalent haptens were less effective than multivalent haptens [ex. BPO15 conjugated to a polylysine (PLL)]. It was found that the maximally effective elicitation of wheal-and-flare was actually induced by trivalent haptens [BPO6-Lys7]. This allowed for the optimal distances between haptenic groups. The maximum antibody-hapten molecular ratios in precipitates in extreme antibody excess were equal to average numbers of BPO groups per molecule.

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