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Title: A survey of the prevalence of penicillin-specific IgG, IgM and IgE antibodies detected by ELISA and defined by hapten inhibition, in patients with suspected penicillin allergy and in healthy volunteers.
identifier: 1675356
description:
epitope description:benzylpenicilloyl group
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 3358899
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1005645
landingPage: http://www.iedb.org/assay/1675356
type:
Literature
publicationVenue:
Br J Clin Pharmacol
dates:
1988
study type: b cell assays
subject species:
fullName:
G Christie
J W Coleman
S Newby
A McDiarmaid-Gordon
J P Hampson
A M Breckenridge
B K Park
method:
antigen inhibition
name:
A survey of the prevalence of penicillin-specific IgG, IgM and IgE antibodies detected by ELISA and defined by hapten inhibition, in patients with suspected penicillin allergy and in healthy volunteers.
description:
For a donor with both IgG and IgE reactivity to Benzilpenicilloyl (BPO)-HSA, inhibition of IgE binding was tested for a series of related compounds. Several different conjugates of BPO inhibited strongly, while Benzilpenicilloic acid inhibited weakly and Benzilpenicillin was not inhibitory, as were the related structures Benzilpenilloic acid, Benzilpenicilleic acid, Ampicillin and Ampicillinoyl-HSA.

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