HLA-DQB1*0602 determines disease susceptibility in a new ""humanized"" multiple sclerosis model in HLA-DR15 (DRB1*1501;DQB1*0602) transgenic mice.

Title:

HLA-DQB1*0602 determines disease susceptibility in a new ""humanized"" multiple sclerosis model in HLA-DR15 (DRB1*1501;DQB1*0602) transgenic mice.

Dataset

identifier:	1677955
description:	epitope description:PRPEVRPPPAKQRPPQKSKQQPRSS antigen name:Myelin-associated oligodendrocyte basic protein host organism:Mus musculus DQB1*0602 Tg
aggregation:	instance of dataset
availability:	available
primaryPublications:	19648275

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1016494
landingPage:	http://www.iedb.org/assay/1677955

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	2009

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Nathali Kaushansky Daniel M Altmann Stephanie Ascough Chella S David Hans Lassmann Avraham Ben-Nun

Data Type

method:	ELISA

Study

name:	HLA-DQB10602 determines disease susceptibility in a new ""humanized"" multiple sclerosis model in HLA-DR15 (DRB11501;DQB1*0602) transgenic mice.
description:	The epitope-reactive Abs were primarily of IgG1 and IgG2b isotypes; the levels of IgG1 isotypes were at least 2-fold higher than those of IgG2b isotype.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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