Generation of biologically active anti-Cryptococcus neoformans IgG, IgE and IgA isotype switch variant antibodies by acridine orange mutagenesis.

Title:

Generation of biologically active anti-Cryptococcus neoformans IgG, IgE and IgA isotype switch variant antibodies by acridine orange mutagenesis.

identifier:	1678500
description:	epitope description:glucuronoxylomannan host organism:Mus musculus BALB/c antibody name:3E5.gamma2a
aggregation:	instance of dataset
availability:	available
primaryPublications:	8809131

study type:	b cell assays
subject species:	Cryptococcus neoformans var. neoformans Serotype A

fullName:	G Spira M Paizi S Mazar G Nussbaum S Mukherjee A Casadevall

method:	biological activity

name:	Generation of biologically active anti-Cryptococcus neoformans IgG, IgE and IgA isotype switch variant antibodies by acridine orange mutagenesis.
description:	The epitope-specific mAb reduced the C. neoformans colony-forming units following incubation with macrophage-like THP-1 cells.

name:	iedb
homePage:	http://www.iedb.org

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