Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.

Title:

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.

identifier:	1683644
description:	epitope description:GPPGARGLTGRPGDAGPP + CITR(R11) host organism:Mus musculus C57BL/10.Q antibody name:GB8
aggregation:	instance of dataset
availability:	available
primaryPublications:	19204106

study type:	b cell assays
subject species:

fullName:	Hü seyin Uysal Robert Bockermann Kutty S Nandakumar Bettina Sehnert Estelle Bajtner Ake Engströ m Guy Serre Harald Burkhardt Marjolein M G M Thunnissen Rikard Holmdahl

method:	ELISA

name:	Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.
description:	There was hydroxylation on proline residues 3, 12 and 18 of the epitope. The epitope specific mAb recognized the epitope by ELISA at a high level and also strongly reacted with the noncitrullinated form of the epitope. The mAb also recognized the epitope citrullinated on residue 6 (pCII-Cit1) or citrullinated on residues 6 and 11 (pCII-Cit1+2) with intermediate reactivity.

name:	iedb
homePage:	http://www.iedb.org

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