Demonstration of phosphorylcholine-specific IgE B cells in CBA/N mice. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Demonstration of phosphorylcholine-specific IgE B cells in CBA/N mice.

Dataset

identifier:	1683242
description:	epitope description:phosphocholine host organism:Mus musculus CBA antibody name:Mouse sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	381515

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1016794
landingPage:	http://www.iedb.org/assay/1683242

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	1979

Dimension

study type:	b cell assays
subject species:

Person

fullName:	T Kishimoto S Shigemoto T Watanabe Y Yamamura

Data Type

method:	antigen inhibition

Study

name:	Demonstration of phosphorylcholine-specific IgE B cells in CBA/N mice.
description:	When 1 ml of 0.3 M free PC was administered just before challenging with PC-BSA, the passive cutaneous anaphylaxis (PCA) reaction induced with PC-BSA was almost completely suppressed, demonstrating the specificity of the IgE to PC. This inhibition was also observed in (CBA/N X BALB/c)F1 mice. The presence of T15 idiotype on anti-PC IgE antibody produced in CBA/N x BALB/c F1 male mice also showed that anti-PC IgE antibody in anti-PC IgM defective mice was PC-specific.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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