An IgM anti-MBP Ab in a case of Waldenstrom's macroglobulinemia with polyneuropathy expressing an idiotype reactive with an MBP epitope immunodominant in MS and EAE.

Title:

An IgM anti-MBP Ab in a case of Waldenstrom's macroglobulinemia with polyneuropathy expressing an idiotype reactive with an MBP epitope immunodominant in MS and EAE.

Dataset

identifier:	1688596
description:	epitope description:TPRTPPPSQGKGRGLSLSRFSWGA antigen name:Myelin basic protein (UniProt:P02686) host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	11137588

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1006906
landingPage:	http://www.iedb.org/assay/1688596

Publication

type:	Literature
publicationVenue:	J Neuroimmunol
dates:	2001

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	B D Noerager T Inuzuka J Kira J E Blalock J N Whitaker F S Galin

Data Type

method:	ELISA

Study

name:	An IgM anti-MBP Ab in a case of Waldenstrom's macroglobulinemia with polyneuropathy expressing an idiotype reactive with an MBP epitope immunodominant in MS and EAE.
description:	The epitope sequence was from the cited reference: Kamholz, J. et al. Proc. Natl. Acad. Sci.USA 1986, 83, 4962-4966. [PMID: 2425357]. The peptide of human MBP 84-96 (NPVVHFFKNIVTP) was the minimal /optimal epitope, despite positive reactivity of ohter peptides of human MBP (108-118, 98-118, 95-118 and 90-118).

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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