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identifier: 1691745
description:
epitope description:YSPTSPS
antigen name:DNA-directed RNA polymerase II subunit RPB1
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 8912511
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1007405
landingPage: http://www.iedb.org/assay/1691745
type:
Literature
publicationVenue:
Arthritis Rheum
dates:
1996
study type: b cell assays
subject species: Homo sapiens
fullName:
M Hirakata
J Kanungo
A Suwa
Y
J Craft
J A Hardin
method:
antigen inhibition
name:
Autoimmunity to RNA polymerase II is focused at the carboxyl terminal domain of the large subunit.
description:
The epitope, conjugated to a peptide representing 1.5 heptapeptide repeats of the epitope, but not the free peptide, was able to inhibit immunoprecipitation of Pol II from Hela cell extracts, by the patient sera. The inhibition was complete for 5 sera tested, and partial for 4.

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