Autoantigenic epitopes of the B and D polypeptides of the U1 snRNP. Analysis of domains recognized by the Y12 monoclonal anti-Sm antibody and by patient sera.

Title:

Autoantigenic epitopes of the B and D polypeptides of the U1 snRNP. Analysis of domains recognized by the Y12 monoclonal anti-Sm antibody and by patient sera.

Dataset

identifier:	1692092
description:	epitope description:MGRGAPPPGMMG antigen name:Small nuclear ribonucleoprotein-associated proteins B and B' host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	7682245

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1007353
landingPage:	http://www.iedb.org/assay/1692092

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	1993

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	M Hirakata J Craft J A Hardin

Data Type

method:	antigen inhibition

Study

name:	Autoantigenic epitopes of the B and D polypeptides of the U1 snRNP. Analysis of domains recognized by the Y12 monoclonal anti-Sm antibody and by patient sera.
description:	The epitope was coupled to BSA though a C-terminal cys residue. An unconjugated form of the peptide competed with the conjugated form for binding in ELISA. In 2 patients, the response to the epitope decreased over 5 years.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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