Role of L2 cysteines in papillomavirus infection and neutralization. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Role of L2 cysteines in papillomavirus infection and neutralization.

Dataset

identifier:	1695650
description:	epitope description:QLYKTCKQAGTCPPDIIPKV antigen name:Minor capsid protein L2 host organism:Mus musculus BALB/c antibody name:RG-1
aggregation:	instance of dataset
availability:	available
primaryPublications:	19860897

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017719
landingPage:	http://www.iedb.org/assay/1695650

Publication

type:	Literature
publicationVenue:	Virol J
dates:	2009

Dimension

study type:	b cell assays
subject species:	Human papillomavirus type 16

Person

fullName:	Ratish Gambhira Subhashini Jagu Balasubramanyam Karanam Patricia M Day Richard Roden

Data Type

method:	western blot

Study

name:	Role of L2 cysteines in papillomavirus infection and neutralization.
description:	The epitope sequence was found in the reference Gambhira et al., J Virol. 2007 Dec 81(24):13927-31, [PMID 17928339]. The epitope-specific mAb was tested for binding to purified HPV 16 virions containing a wild-type and mutated epitope in the L2 protein. The mAb showed positive binding to the wild-type epitope. Single alanine substitutions were made to the epitope. Single substitutions K4A, C6A and C12A eliminated mAb binding and P13A greatly reduced mAb recognition.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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