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Title: Cross-recognition between histones and La/SSB may account for anti-DNA reactivity in SLE patients.
identifier: 1692791
description:
epitope description:GSGKGKVQFQGKKTKF + ACET(G1)
antigen name:Lupus La protein
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 16178873
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1007247
landingPage: http://www.iedb.org/assay/1692791
type:
Literature
publicationVenue:
Clin Exp Immunol
dates:
2005
study type: b cell assays
subject species: Homo sapiens
fullName:
E Touloupi
J G Routsias
A G Tzioufas
method:
ELISA
name:
Cross-recognition between histones and La/SSB may account for anti-DNA reactivity in SLE patients.
description:
The epitope-specific antibody responses appeared early in the disease course, varied in time and could not be correlated with the duration of the disease. The titre of epitope-specific antibody varied in parallel with anti-dsDNA antibody titre. The anti-dsDNA serum activity could be inhibited by the epitope at 95%, and the epitope-specific serum activity could be inhibited by dsDNA at 70%.

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