Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1006984 |
| landingPage: |
http://www.iedb.org/assay/1693627 |
| type: |
Literature
|
| publicationVenue: |
Eur J Immunol
|
| dates: |
2001
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
P Eftekhari
J C Roegel
F Lezoualc'h
R Fischmeister
J L Imbs
J Hoebeke
|
| method: |
in vivo assay
|
| name: |
Induction of neonatal lupus in pups of mice immunized with synthetic peptides derived from amino acid sequences of the serotoninergic 5-HT4 receptor.
|
| description: |
Fertility of epitope-immunized mice was significantly lower than that of the controls and was correlated with the antibody titer of the individual mice. Pups from mice immunized with the epitope had bradycardia, atrioventricular block of type I or II, longer QT intervals, skin rashes and neuromotoric problems. Hearts from diseased pups were less developed and showed disorganized myocardial hyperplasia, compared to the normal littermates.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
