Myasthenia gravis and the tops and bottoms of AChRs: antigenic structure of the MIR and specific immunosuppression of EAMG using AChR cytoplasmic domains.

Title:

Myasthenia gravis and the tops and bottoms of AChRs: antigenic structure of the MIR and specific immunosuppression of EAMG using AChR cytoplasmic domains.

Dataset

identifier:	1694019
description:	epitope description:KWNPDDYGGVK antigen name:Acetylcholine receptor subunit alpha (UniProt:P02708) host organism:Rattus norvegicus Lewis antibody name:210
aggregation:	instance of dataset
availability:	available
primaryPublications:	18567851

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017012
landingPage:	http://www.iedb.org/assay/1694019

Publication

type:	Literature
publicationVenue:	Ann N Y Acad Sci
dates:	2008

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Jon Lindstrom Jie Luo Alexander Kuryatov

Data Type

method:	immunoprecipitation

Study

name:	Myasthenia gravis and the tops and bottoms of AChRs: antigenic structure of the MIR and specific immunosuppression of EAMG using AChR cytoplasmic domains.
description:	The epitope sequence is from the reference cited: Tzartos (1998) Immunol Rev 163: 89-120 [PMID: 9700504]. Rat mAb 210 immunoprecipitated human alpha1/alpha7chimera containing residues 66-76 of alpha1, demonstrating this is the epitope recognized by the mAbs. Increasing the length of the alpha1 insert to residues 60-81 did not improve binding.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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