Murine IgG isotype responses to the Plasmodium cynomolgi circumsporozoite peptide (NAGG)5. I. Effects of carrier, copolymer adjuvants, and lipopolysaccharide on isotype selection.

Title:

Murine IgG isotype responses to the Plasmodium cynomolgi circumsporozoite peptide (NAGG)5. I. Effects of carrier, copolymer adjuvants, and lipopolysaccharide on isotype selection.

Dataset

identifier:	1694107
description:	epitope description:NAGG antigen name:Circumsporozoite protein host organism:Mus musculus ICR
aggregation:	instance of dataset
availability:	available
primaryPublications:	2026882

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017808
landingPage:	http://www.iedb.org/assay/1694107

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	1991

Dimension

study type:	b cell assays
subject species:	Plasmodium cynomolgi

Person

fullName:	M L Kalish I J Check R L Hunter

Data Type

method:	ELISA

Study

name:	Murine IgG isotype responses to the Plasmodium cynomolgi circumsporozoite peptide (NAGG)5. I. Effects of carrier, copolymer adjuvants, and lipopolysaccharide on isotype selection.
description:	IgG responses to the epitope MAP conjugated to BSA was measured. Peptide-BSA alone induced no detectable primary IgG response, and only a small secondary IgG titer. In contrast, immunization with adjuvants induced primary titers of IgG antibodies of 2800 with LPS and 7000 with L121. With LPS, the secondary titer rose approximately threefold. The two copolymer adjuvants elicited equivalent secondary responses that were higher than those induced with LPS. Immunization with the copolymer L141 plus LPS produced the highest titer. The predominant IgG isotype was identified as IgG1.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.