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Title: Suppression of experimental myasthenia gravis by a B-cell epitope-free recombinant acetylcholine receptor.
identifier: 1695266
description:
epitope description:KWNPDDYGGVK
antigen name:Acetylcholine receptor subunit alpha (UniProt:P02708)
host organism:Rattus norvegicus Lewis
aggregation:
instance of dataset
availability:
available
primaryPublications: 18799218
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1013087
landingPage: http://www.iedb.org/assay/1695266
type:
Literature
publicationVenue:
Mol Immunol
dates:
2008
study type: b cell assays
subject species: Homo sapiens
fullName:
Hwa-Jung Yi
Chang-Suk Chae
Jae-Seon So
Socrates J Tzartos
Miriam C Souroujon
Sara Fuchs
Sin-Hyeog Im
method:
ELISA
name:
Suppression of experimental myasthenia gravis by a B-cell epitope-free recombinant acetylcholine receptor.
description:
The epitope sequence is from the reference cited: Tzartos (1998) Proc Natl Acad Sci USA 85: 2899-2903 [PMID:3362855]. The epitope sequence is identical in acetylcholine receptor subunit alpha from rat.
Sera from myasthenic rats recognized the epitope as deduced by their reduced reactivity with human AChR alpha-subunit fragment 1-210 with deletion of the epitope, residues 67-76. Deletion of another B cell epitope, residues 129-145, or both regions also significantly reduced reactivity by ELISA and Western blotting.

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