Monoclonal antibodies to the West Nile virus NS5 protein map to linear and conformational epitopes in the methyltransferase and polymerase domains.

Title:

Monoclonal antibodies to the West Nile virus NS5 protein map to linear and conformational epitopes in the methyltransferase and polymerase domains.

Dataset

identifier:	1697959
description:	epitope description:QRVFKEKVDTKAPEPP antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:5C11
aggregation:	instance of dataset
availability:	available
primaryPublications:	19710254

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017769
landingPage:	http://www.iedb.org/assay/1697959

Publication

type:	Literature
publicationVenue:	J Gen Virol
dates:	2009

Dimension

study type:	b cell assays
subject species:	Kunjin virus

Person

fullName:	Roy A Hall Si En Tan Barbara Selisko Rachael Slade Jody Hobson-Peters Bruno Canard Megan Hughes Jason Y Leung Ezequiel Balmori-Melian Sonja Hall-Mendelin Kim B Pham David C Clark Natalie A Prow Alexander A Khromykh

Data Type

method:	cross blocking

Study

name:	Monoclonal antibodies to the West Nile virus NS5 protein map to linear and conformational epitopes in the methyltransferase and polymerase domains.
description:	The epitope sequence was found in the reference Coia et al., J Gen Virol. 1988 Jan 69 ( Pt 1):1-21, [PMID: 2826659]. The epitope-specific mAb inhibited anti-NS5 mAb binding to full-length RdRp in competitivie ELISA and also bound to full-length and truncated recombinant NS5 proteins from bacterial cell lysates in dot-blot analysis.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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